abstract：OBJECTIVE:Stage is a critical determinant of prognosis and treatment for endometrial cancer (EC) patients. Women who have had a tubal ligation for sterilization have improved EC survival, secondary to lower stage at presentation, suggesting that transtubal spread may represent an important route of metastasis. We evalu...

journal_title：Gynecologic oncology

authors： Felix AS,Sinnott JA,Vetter MH,Rhoades J,Cohn DE,Backes FJ,Sherman ME,Suarez AA

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:We performed a phase I, single-arm, non-randomized, open-label, dose-escalation trial to determine the dose-limiting toxicity of intraperitoneal cisplatin and doxorubicin applied as pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with recurrent ovarian cancer. METHODS:We used a standard 3 +...

journal_title：Gynecologic oncology

authors： Tempfer CB,Giger-Pabst U,Seebacher V,Petersen M,Dogan A,Rezniczek GA

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this case-controlled study was to determine the prevalence of anemia and incidence of perioperative blood transfusions in patients undergoing treatment for advanced ovarian cancer with neoadjuvant chemotherapy (NACT) or primary debulking surgery (PDS). METHODS:We performed a single institution...

journal_title：Gynecologic oncology

authors： O'Shea A,McCool K,Harrison R,Sampene E,Connor J,Barroilhet L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Chemotherapy-induced peripheral neuropathy (CIPN) presents itself as sensory peripheral neuropathy (SPN) or motor peripheral neuropathy (MPN). Our aim was to examine the course of SPN and MPN, and their impact on health-related quality of life (HRQoL) among ovarian cancer patients. METHODS:All newly diagnose...

journal_title：Gynecologic oncology

authors： Bonhof CS,Mols F,Vos MC,Pijnenborg JMA,Boll D,Vreugdenhil G,Ezendam NPM,van de Poll-Franse LV

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:We compared the self-sampling performance of the newly designed HerSwab™ device with a physician-collected cervical sample and another self-sample using the cobas® PCR Female swab for the detection of cervical intraepithelial neoplasia (CIN) and cancer. METHODS:Women referred for colposcopy at McGill Univers...

journal_title：Gynecologic oncology

authors： El-Zein M,Bouten S,Louvanto K,Gilbert L,Gotlieb W,Hemmings R,Behr MA,Franco EL,CASSIS Study Group.

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To determine, in patients with non-endometrioid endometrial carcinoma, 1) survival benefit associated with pelvic lymphadenectomy (LND), 2) survival benefit for para-aortic lymphadenectomy performed in addition to pelvic lymphadenectomy, and 3) association between number of lymph nodes removed and survival. ME...

journal_title：Gynecologic oncology

authors： Venigalla S,Chowdhry AK,Shalowitz DI

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Human papillomavirus (HPV) infection is the primary cause of cervical cancer. HPV-mediated immune alterations are known to play crucial roles in determining viral persistence and host cell transformation. We sought to thoroughly understand HPV-directed immune alterations in cervical cancer by exploring public...

journal_title：Gynecologic oncology

authors： Chen L,Luan S,Xia B,Liu Y,Gao Y,Yu H,Mu Q,Zhang P,Zhang W,Zhang S,Wei G,Yang M,Li K

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To increase genetic counseling referrals for patients with newly diagnosed epithelial ovarian cancer (EOC). METHODS:A practice-gap analysis was performed after measuring baseline genetic counseling referral rates to identify barriers to referral from the multidisciplinary single institution EOC care group. A...

journal_title：Gynecologic oncology

authors： Swanson CL,Kumar A,Maharaj JM,Kemppainen JL,Thomas BC,Weinhold MR,Slaby KM,Mara KC,Wick MJ,Bakkum-Gamez JN

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Population-based studies of women with epithelial ovarian cancer suggest that black women have worse survival compared to white women. The primary objective of this study was to determine if, at a National Cancer Institute (NCI)-Designated Comprehensive Cancer Center (CCC) serving a diverse racial and socioe...

journal_title：Gynecologic oncology

authors： Dilley S,Erickson BK,Phillips CE,Kennemer CR,Zhang B,Matin T,Martin JY,Shah MM,Michael Straughn J Jr,Leath CA 3rd

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS:Patients with node-positive cervical cancer treated curative...

journal_title：Gynecologic oncology

authors： Bacorro W,Dumas I,Escande A,Gouy S,Bentivegna E,Morice P,Haie-Meder C,Chargari C

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:To report the intermediate-term results of trans-abdominal ultrasound (TAUS)-guided brachytherapy in cervical cancer. MATERIALS AND METHODS:Ninety-two patients with cervical cancer (stage IB-IVA, according to FIGO staging), were treated by curative radiotherapy from February 2012 to June 2015. All patients ...

journal_title：Gynecologic oncology

authors： Tharavichitkul E,Chakrabandhu S,Klunklin P,Onchan W,Jia-Mahasap B,Wanwilairat S,Tippanya D,Jayasvasti R,Sripan P,Galalae RM,Chitapanarux I

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS:LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosom...

journal_title：Gynecologic oncology

authors： Filippov-Levy N,Cohen-Schussheim H,Tropé CG,Hetland Falkenthal TE,Smith Y,Davidson B,Reich R

更新日期：2018-03-01 00:00:00

abstract：:The Precision Medicine Initiative is a National Cancer Institute (NCI) driven interdisciplinary collaborative effort to test the feasibility of trials incorporating genomic profiling when choosing patient therapies. The goal of the initiative is to generate the scientific evidence needed to move the concept of precisi...

journal_title：Gynecologic oncology

authors： Barroilhet L,Matulonis U

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The expression of homologous recombination (HR) genes in high grade ovarian cancer (HGOC) samples from debulking surgeries were correlated to outcomes in patients selected for chemotherapy treatment regimens. STUDY DESIGN:RNA was extracted from 96 fresh frozen tumor samples from debulking surgeries from chem...

journal_title：Gynecologic oncology

authors： Kessous R,Octeau D,Klein K,Tonin PN,Greenwood CMT,Pelmus M,Laskov I,Kogan L,Salvador S,Lau S,Yasmeen A,Gotlieb WH

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the expression, and effect of targeting CD11b with a monoclonal antibody in ovarian cancer cells. METHODS:CD11b expression was determined in epithelial ovarian cancer (EOC) cell lines and tissues by immunofluorescence and flow cytometry. Cytotoxicity of the CD11b ...

journal_title：Gynecologic oncology

authors： Saed GM,Fletcher NM,Diamond MP,Morris RT,Gomez-Lopez N,Memaj I

更新日期：2018-03-01 00:00:00

abstract：:The incidence of endometrial cancer (EC) in the U.S. has been rising, from an estimated annual incidence of 49,560 in 2013 to 61,380 in 2017. Meanwhile, the SEER-based relative survival of women with EC in the U.S. has remained flat [82.3% from 1987 to 1989, 82.8% from 2007 to 2013] and our recent increased understand...

journal_title：Gynecologic oncology

authors： Lheureux S,McCourt C,Rimel BJ,Duska L,Fleming G,Mackay H,Mutch D,Temkin SM,Lynn J,Kohn EC

更新日期：2018-02-22 00:00:00

abstract：OBJECTIVE:Although the relationship between human papilloma virus (HPV) and cervical cancer is well established, the prognostic value of HPV status has not been determined, largely because previous studies have yielded conflicting results. This study aimed to investigate the prognostic value of pre-treatment HPV DNA fo...

journal_title：Gynecologic oncology

authors： Chong GO,Lee YH,Han HS,Lee HJ,Park JY,Hong DG,Lee YS,Cho YL

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Advanced ovarian cancer (OC) commonly spreads to cardiophrenic lymph nodes (CPLNs), and is often visible on preoperative imaging. We investigated the prognostic significance of abnormal CPLNs in OC detected by preoperative CT scans using three different definitions. METHODS:Patients undergoing primary debulk...

journal_title：Gynecologic oncology

authors： Mert I,Kumar A,Sheedy SP,Weaver AL,McGree ME,Kim B,Cliby WA

更新日期：2018-01-01 00:00:00

abstract：STUDY OBJECTIVE:To describe our technique for excision of the pre-caval and laterocaval nodes using an extraperitoneal approach. This technique was developed to make the dissection and excision of the less accessible nodes in an easier and safer way by minimizing the risk of great vessels injury and bleeding. DESIGN:S...

journal_title：Gynecologic oncology

authors： Gorostidi M,Villalain C,Ruiz R,Jaunarena I,Lekuona A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Small cell carcinoma of the ovary, hypercalcemic-type (SCCOHT) is a rare, extremely aggressive neoplasm that usually occurs in young women and is characterized by deleterious germline or somatic SMARCA4 mutations. We performed comprehensive genomic profiling (CGP) to potentially identify additional clinically...

journal_title：Gynecologic oncology

authors： Lin DI,Chudnovsky Y,Duggan B,Zajchowski D,Greenbowe J,Ross JS,Gay LM,Ali SM,Elvin JA

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To evaluate C-reactive protein (CRP) serum levels as a preoperative predictive marker for ovarian cancer in patients with adnexal masses. METHODS:CRP serum levels of 1843 adnexal masses and subsequent surgery were investigated (patients with benign ovarian tumors: n=1423; borderline tumor of the ovary [BTO]:...

journal_title：Gynecologic oncology

authors： Reiser E,Aust S,Seebacher V,Reinthaller A,Helmy-Bader S,Schwameis R,Grimm C,Polterauer S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Glucocorticoid receptor (GR) has emerged as an important steroid nuclear receptor in hormone dependent cancers, however few data are available regarding a potential role of GR in endometrial cancer. The aim of this study was to investigate expression of GR in primary and metastatic endometrial cancer lesions...

journal_title：Gynecologic oncology

authors： Tangen IL,Veneris JT,Halle MK,Werner HM,Trovik J,Akslen LA,Salvesen HB,Conzen SD,Fleming GF,Krakstad C

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Melanoma originating from gynecologic sites (MOGS), including the vulva, vagina, and cervix, is a rare and aggressive form of melanoma with poor long-term clinical outcome. The clinicopathologic features of vulvar and non-vulvar tumors remain relatively understudied, and in contrast to cutaneous melanomas at ...

journal_title：Gynecologic oncology

authors： Udager AM,Frisch NK,Hong LJ,Stasenko M,Johnston CM,Liu JR,Chan MP,Harms PW,Fullen DR,Orsini A,Thomas DG,Lowe L,Patel RM

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) in primary treatment of advanced ovarian cancer has not been widely studied. We report on a cohort of patients undergoing CPLN resection during primary cytoreductive surgery (CRS), examining its feasibility, safety, and potential impact on clin...

journal_title：Gynecologic oncology

authors： Cowan RA,Tseng J,Murthy V,Srivastava R,Long Roche KC,Zivanovic O,Gardner GJ,Chi DS,Park BJ,Sonoda Y

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Six cycles of consolidation chemotherapy have become the standard for ovarian cancer treatment regimen following primary cytoreduction, yet with neoadjuvant chemotherapy (NAC), only 3 consolidation cycles are used. This study examines the effects of number of chemotherapy cycles in women with ovarian cancer ...

journal_title：Gynecologic oncology

authors： Altman AD,McGee J,May T,Lane K,Lu L,Xu W,Ghatage P,Rosen B

更新日期：2017-11-01 00:00:00

abstract：:MicroRNA molecules are small, single-stranded RNA molecules that function to regulate networks of genes. They play important roles in normal female reproductive tract biology, as well as in the pathogenesis and progression of epithelial ovarian cancer. DROSHA, DICER, and Argonaute proteins are components of the microR...

journal_title：Gynecologic oncology

authors： Wang X,Ivan M,Hawkins SM

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage ...

journal_title：Gynecologic oncology

authors： Fader AN,Bergstrom J,Jernigan A,Tanner EJ 3rd,Roche KL,Stone RL,Levinson KL,Ricci S,Wethingon S,Wang TL,Shih IM,Yang B,Zhang G,Armstrong DK,Gaillard S,Michener C,DeBernardo R,Rose PG

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:An epigenetic approach to explaining endometrial carcinogenesis necessitates good understanding of Ras association domain family 1 isoform A (RASSF1A) promoter methylation data from primary studies. AIMS:Differential magnitude of reported associations between RASSF1A promoter methylation and endometrial can...

journal_title：Gynecologic oncology

authors： Pabalan N,Kunjantarachot A,Ruangpratheep C,Jarjanazi H,Christofolini DM,Barbosa CP,Bianco B

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether DNA ploidy correlates with the four molecular subgroups of endometrial carcinoma (EC) as determined using ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). METHODS:90 cases of EC previously characterized by clinicopathological parameters, outcomes, and ProMi...

journal_title：Gynecologic oncology

authors： Proctor L,Pradhan M,Leung S,Cheng A,Lee CH,Soslow RA,Gilks CB,Talhouk A,McAlpine JM,Danielsen HE,Hoang LN

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Participation in clinical and basic science research is emphasized in gynecologic oncology training. We sought to identify trends in adherence to expected research practices and reasons for non-adherence among gynecologic oncology fellows. METHODS:An anonymous 31-question online survey assessing academic be...

journal_title：Gynecologic oncology

authors： Moulton LJ,Michener CM,Levinson K,Cobb L,Tseng J,Jernigan A

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To determine whether written information and/or counseling based on the WOMAN-PRO II Program decreases symptom prevalence in women with vulvar neoplasia by a clinically relevant degree, and to explore the differences between the 2 interventions in symptom prevalence, symptom distress prevalence, and symptom e...

journal_title：Gynecologic oncology

authors： Raphaelis S,Mayer H,Ott S,Mueller MD,Steiner E,Joura E,Senn B

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Ovarian carcinomas that originate from fallopian epithelial cells are suggested to arise due to repeated exposure to ovulatory follicular fluid (FF). Mechanistic explanation(s) for how this occurs are unknown. Here, we sought to understand if FF exposure to fallopian epithelial cells could induce DNA damage a...

journal_title：Gynecologic oncology

authors： Brachova P,Alvarez NS,Van Voorhis BJ,Christenson LK

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To estimate the survival benefit and cost-effectiveness of performing hysterectomy during risk-reducing salpingo-oophorectomy (RRSO) for BRCA1 mutation carriers. METHODS:Based on a recent prospective cohort study indicating an elevated incidence of serous/serous-like uterine cancers among BRCA1 mutation carr...

journal_title：Gynecologic oncology

authors： Havrilesky LJ,Moss HA,Chino J,Myers ER,Kauff ND

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS:This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from pati...

journal_title：Gynecologic oncology

authors： Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2017-06-01 00:00:00

abstract：:While many investigators have described the biochemical and physiological similarities between tumor cells and trophoblast cells, in this discourse we will compare primarily their leucocytes, which constitute a large portion of the tumor and its microenvironment as well as the placenta and its microenvironment. There ...

journal_title：Gynecologic oncology

authors： Beaman KD,Dambaeva S,Katara GK,Kulshrestha A,Gilman-Sachs A

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:There is uncertainty surrounding the prognostic value and clinical utility of peritoneal cytology in endometrial cancer. Our primary objective was to determine if positive cytology is associated with disease-free and overall survival in women treated surgically for endometrial cancer, specifically those with...

journal_title：Gynecologic oncology

authors： Scott SA,van der Zanden C,Cai E,McGahan CE,Kwon JS

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Intraperitoneal (IP) therapy improves survival compared to intravenous (IV) treatment for women with newly diagnosed, optimally cytoreduced, ovarian cancer. However, the role of IP therapy in recurrent disease is unknown. Preclinical data demonstrated IP administration of the proteasome inhibitor, bortezomib pr...

journal_title：Gynecologic oncology

authors： Jandial DA,Brady WE,Howell SB,Lankes HA,Schilder RJ,Beumer JH,Christner SM,Strychor S,Powell MA,Hagemann AR,Moore KN,Walker JL,DiSilvestro PA,Duska LR,Fracasso PM,Dizon DS

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:This study explores patterns of lifestyle change and whether more threatening illness perceptions are associated with lifestyle changes post-treatment for smoking, alcohol consumption and Body Mass Index (BMI) among gynecological cancer patients. METHODS:In total, 395 cancer patients (N=221 endometrial; N=17...

journal_title：Gynecologic oncology

authors： van Broekhoven MECL,de Rooij BH,Pijnenborg JMA,Vos MC,Boll D,Kruitwagen RFPM,van de Poll-Franse LV,Ezendam NPM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS:Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox...

journal_title：Gynecologic oncology

authors： Seagle BL,Kanis M,Kocherginsky M,Strauss JB,Shahabi S

更新日期：2017-04-01 00:00:00

abstract：:Ernst Wertheim was a pioneer in the history of the surgical treatment of cervical cancer. His English-language manuscript "The extended abdominal operation for carcinoma uteri (based on 500 operative cases)," which was published in 1912, detailed his standardization of the radical hysterectomy and formed the basis of ...

journal_title：Gynecologic oncology

authors： Swailes AL,Gockley A,Phaëton R,Kesterson JP

更新日期：2017-04-01 00:00:00